Chris Ekpenyong (1999–2005)#
Served under Victor Attah · PDP Tenure: 29 May 1999 — July 2005
Mode in: Elected on the Attah joint ticket, 1999; re-elected 2003.
Mode out: Left office after a political breach with the governor.
Michael Udofia (2005–2007)#
Served under Victor Attah · PDP Tenure: July 2005 — 29 May 2007
Mode in: Appointed to fill the vacancy.
Mode out: End of term.
Patrick Ekpotu (2007–2011)#
Served under Godswill Akpabio · PDP Tenure: 29 May 2007 — 29 May 2011
Mode in: Elected on the Akpabio joint ticket, 2007.
Mode out: Not renominated for the 2011 ticket.
Nsima Ekere (2011–2012)#
Served under Godswill Akpabio · PDP Tenure: 29 May 2011 — November 2012
Mode in: Elected on the Akpabio joint ticket, 2011.
Mode out: Resigned.
Later Managing Director of the Niger Delta Development Commission.
Valerie Ebe (2012–2015)#
Served under Godswill Akpabio · PDP Tenure: November 2012 — 29 May 2015
Mode in: Appointed after Ekere's resignation.
Mode out: End of term.
One of the few women to hold the office in the South-South.
Moses Ekpo (2015–2023)#
Served under Udom Emmanuel · PDP Tenure: 29 May 2015 — 29 May 2023
Mode in: Elected on the Emmanuel joint ticket, 2015; re-elected 2019.
Mode out: End of term.
Akon Eyakenyi (2023–present)#
Served under Umo Eno · PDP Tenure: 29 May 2023 — present
Mode in: Elected on the Eno joint ticket, 2023.
Mode out: In office.
Former Federal Minister of Lands, Housing and Urban Development.